123rd General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Life Chemist
Room No. Room 303
Time THU 09:00-09:15
Code LIFE.O-1
Subject Nitric Oxide-Scavenging Nanogel for Treating Rheumatoid Arthritis
Authors JIwon Yeo, Junseok Lee1, Won jong Kim2,*
Chemistry, Pohang University of Science and Technology, Korea
1Pohang University of Science and Technology, Korea
2Department of Chemistry, Pohang University of Science and Technology, Korea
Abstract Nitric oxide (NO), a radical gas molecule produced by nitric oxide synthase (NOS), plays a key role in the human body. However, when endogenous NO is overproduced by physiological disorders, severe inflammatory diseases such as rheumatoid arthritis (RA) can occur. Therefore, scavenging NO may be an alternative strategy for treating inflammatory disorders. In our previous study, we developed a NO-responsive macro-sized hydrogel by incorporating an NO-cleavable crosslinker (NOCCL); here, we further evaluated the effectiveness of the NO-scavenging nano-sized hydrogel (NO-Scv gel) for treating RA. NO-Scv gel was simply prepared by solution polymerization between acrylamide (Am) and NOCCL. When the NO-Scv gel was exposed to NO, NOCCL was readily cleaved by consuming the NO molecule, as demonstrated in a Griess assay. As expected, the NO-Scv gel reduced inflammation levels by scavenging NO in vitro and showed excellent biocompatibility. Furthermore, the more promising therapeutic effect of the NO-Scv gel in suppressing the onset of RA was observed in vivo in a mouse RA model and compared to the effects of dexamethasone, a commercial drug. Therefore, our findings suggest the potential of the NO-Scv gel for biomedical applications and further clinical translation.
E-mail yue2754@postech.ac.kr