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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-386 |
| Subject |
2-Thioxothiazolidin-4-one derivatives as Pim kinase inhibitors
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| Authors |
Yanghwan Yun, Victor Sukbong Hong, Jinho Lee*
Department of Chemistry, Keimyung University, Korea
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| Abstract |
Overexpression of Pim kinases have been implicated as oncogenic drivers in multiple cancer including lymphoma, leukemia, multiple myeloma, prostate and gastric cancers. Pim kinases (PIM-1, PIM-2, and PIM-3) are involved in many cellular phenomena such as transcription, translation, growth, survival and apoptosis resistance of cancer cell. Thus, Pim kinases are one of the attractive therapeutic targets for the development of anti-cancer agents.
A novel series of 2-thioxothiazolidin-4-one (Rhodanine) derivatives were synthesized as Pim kinases inhibitors. Synthesized compounds showed potent inhibitory activities against Pim kinases. The most potent compound exhibited IC50 values of 0.001 μM for both PIM-1 and PIM-3.
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| E-mail |
zznx17@naver.com |
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123rd General Meeting of the KCS