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| Type |
Poster Presentation |
| Area |
Polymer Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 19일 (금요일) 11:00~12:30 |
| Code |
POLY.P-30 |
| Subject |
Biocompatible Nitrogen Containing Aliphatic Polymer: Electron Transfer based Singlet Oxygen Generator for Photodynamic Therapy |
| Authors |
Jung seung Nam, Chaiheon Lee1, Byeong-Su Kim2,*, Tae-Hyuk Kwon3,*
Department of Chemistry, Ulsan National Institute of Science and Technology, Korea
1Chemistry, Ulsan National Institute of Science and Technology, Korea
2Department of Chemistry, Yonsei University, Korea
3Eco-Friendly Energy Engineering, Ulsan National Institute of Science and Technology, Korea
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| Abstract |
Singlet oxygen generators containing conjugated aromatic group or heavy metal atom have shown good efficacy in PDT, however, the most of materials have had limitations as therapeutic agents because of their poor biocompatibility. Herein, we introduce new type of singlet oxygen generator based on nitrogen of aliphatic polyamino glycerols (PAG), which have excellent biocompatibility. it was confirmed that nitrogen atom on backbone was the source of electron transfer owing to its paramagnetic properties and that generates radical oxygen species (O2•−, HO2•, or H2O2), subsequently converted to singlet oxygen. Additionally, PAG successfully ablated cancer cells by photodynamical pathway. |
| E-mail |
n.jungseung@gmail.com |
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123rd General Meeting of the KCS