123rd General Meeting of the KCS

Type Poster Presentation
Area Polymer Chemistry
Room No. Exhibition Hall 2
Time 4월 19일 (금요일) 11:00~12:30
Code POLY.P-36
Subject Photo-chemically Cross-linked Hydrogels of Elastin-Resilin Block Copolypeptides for Biomedical Applications
Authors Aamna Basheer, Min Jeong Kang1, Jae Hee Lee1, Dong Woo Lim2,*
Department of Bionanotechnology, Hanyang University, Pakistan
1Department of Bionanotechnology, Hanyang University, Korea
2Department of Bionano Engineering, Hanyang University, Korea
Abstract Photo-initiated, chemically-crosslinked polypeptide hydrogels have been of growing interest for biomedical applications because they have significant advantages including biodegradable polypeptides, fast curing rates with biocompatible precursors under physiological conditions, and generation of minimized heat. In this study, we report photo-chemically cross-linked of elastin-resilin triblock copolypeptides composed of thermally responsive elastin-based polypeptide (EBP) as an end block and resilin-based polypeptides (RBP) with resilient property as a hydrophilic middle block. As temperature increased, EBP end block was aggregated into hydrophobic domains and tyrosine residues of RBP middle blocks were then photo-chemically cross-linked in the presence of photo-catalyst via UV irradiation within several minutes. As characterized by rheological experiments, these hydrogels showed enhanced mechanical properties including complex shear modulus, equilibrium shear modulus and equilibrium compressive modulus as compared to those of the physically crosslinked ones. In conclusion, these block copolypeptide hydrogels would be promising for tissue engineering and regenerative medicine applications.
E-mail aamna@hanyang.ac.kr