123rd General Meeting of the KCS

Type Poster Presentation
Area Electrochemistry
Room No. Exhibition Hall 2
Time 4월 18일 (목요일) 11:00~12:30
Code ELEC.P-458
Subject Non-enzyme biosensor using nickel particles immobilized indium tin oxide electrodes for selective detection of uric acid
Authors Chang Jun Lee, Won-Yong Jeon, Young Bong Choi*, Hyug-Han Kim*
Department of Chemistry, Dankook University, Korea
Abstract There was uric acid that act as a bio-marker to detect gout. In biosensor using electrochemical methods, uric acid was difficult to selectively detect due to oxidation reaction by other interfering substances. In addition, there was disadvantage that the enzyme was expensive to use. However, selective quantitative analysis of uric acid was possible at low cost by using nickel particles. First, the polymer, polyvinylimidazole(PVI), is immobilized on the indium tin oxide (ITO) electrode using the electrodeposition method, and then the nickel solution was adsorbed by PVI. After washing modified electrodes, the solution with uric acid was then raised to react with nickel. Finally, modified electrodes was washed once more to remove unattached uric acid with nickel. The electrodes was confirmed through SEM and EDS for morphology and presence of nickel. The electrochemical impedance spectroscopy(EIS) for each substance carried out on the electrode based the changed resistance. Through differential pulse voltammetry(DPV), we plotted the calibration curve for quantitative analysis of uric acid and checked the effect of interference substances in human body such as ascorbic acid, dopamine, and glucose. As a result, this study was showed in the possibility of a biosensor capable of selectively detecting uric acid.
E-mail chang5654@naver.com