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| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-374 |
| Subject |
Hypoxia-Triggered Transforming Immunomodulator for Cancer Immunotherapy via Photodynamically Assisted Antigen Presentation of Dendritic Cell |
| Authors |
Sooseok Im, Won jong Kim1,*
School of Interdisciplinary Bioscience and Bioengi, Pohang University of Science and Technology, Korea
1Department of Chemistry, Pohang University of Science and Technology, Korea
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| Abstract |
Recent tendency of cancer therapy is focused on immunotherapy as an alternative method. In spite of its strong anticancer effect, it has been reported that the immunoediting of cancer is an obstacle for successful immunotherapy. Among the pathways of immunoediting, the continuous mutation induces the heterogeneity of cancer, providing with a means of escape from attack of tumor-specific T cells. However, recent researches have demonstrated that cancer with high mutation rate showed valid therapeutic effect after cancer immunotherapy due to generation of neoantigens. Therefore, a direct release of endogenous tumor antigens from tumor cell itself can be a promising strategy for activation of anti-immune response despite of immunoediting.
Herein, we reported a nanoparticle-based system for combinatorial anticancer therapy by introduction of photodynamic effect into immunotherapy. First, we have fabricated a MSN based nanoparticle whose surface covered with hypoxia-cleavable PEG for enhanced delivery of photosensitizer and adjuvant. The results from tumor infiltrated lymphocyte analysis showed that enriched dendritic cell population at tumor site after photodynamic therapy. Also, the hypoxia-responsible delivery of adjuvants and the release of tumor proteins induced by photodynamic effect results in increase of antigen presentations of the model tumor proteins, showing significant anti-tumor therapeutic effect in tumor regression study in vivo. Taken all together, the application of photodynamic therapy into immunotherapy is promising as recruiting dendritic cells and enhances antigen presentation process
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| E-mail |
ssl0213@postech.ac.kr |
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123rd General Meeting of the KCS