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| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-376 |
| Subject |
Antidiabetic effect of DH049 via inhibition of the protein tyrosine phosphatase PTPN11 |
| Authors |
Dohee Ahn, Do Hwi Kim, Sang Jeon Chung1,*
Pharmacy, Sungkyunkwan University, Korea
1College of Pharmacy, SungKyunKwan University, Korea
|
| Abstract |
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11), a member of the protein tyrosine phosphatase (PTP) family. PTPN11 is a cytoplasmic enzyme widely expressed in various tissues and cells. PTPN11 involved in the tyrosine kinase receptor signaling (EGF, insulin, etc.) stimulates RAS-RAF-MAPK and PI3K/AKT signaling pathway. The alteration of PTPN11 activity leads to abnormal development, tumorigenesis, and metabolic disease. In this study, we have screened natural compounds to identify potent inhibitors of PTPN11. Among them, DH049 was selected as a targeting inhibitor of PTPN11. We examined its Ki value and inhibition type in vitro and investigated the antidiabetic effect of DH049 in 3T3-L1 cells. Thus, these results suggest a valid therapeutic approach for the treatment of diabetes. |
| E-mail |
ehgml94@naver.com |
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123rd General Meeting of the KCS