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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-402 |
| Subject |
A Novel Chalcone Derivative Suppress Inflammation via Nrf2 Activation and Attenuates the Learning and Memory Impairment in Scopolamine-Induced Mouse Model |
| Authors |
Boko Jang, Ki Duk Park*
Convergence Research Center for DTC, Korea Institute of Science and Technology, Korea
|
| Abstract |
Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by progressive degeneration and neuronal cell death, resulting in neural network dysfunction. As the underlying mechanisms, oxidative damage and neuroinflammation have been reported to contribute to the onset and deterioration of AD. Nrf2-ARE signaling pathway is a pivotal cellular defense mechanism against oxidative stress. Nrf2, a transcription factor, regulates the cellular redox balance and is also primarily involved in anti-inflammatory response. Here, we have synthesized novel chalcone derivatives and found a highly potent Nrf2 activator, compound 9a. Compound 9a induced expression of Nrf2-dependent antioxidant enzymes, increased SOD activity, and inhibited reactive oxygen species production. It also suppressed the production of nitric oxide and down-regulated inflammatory mediators confirming its anti-inflammatory effect. In addition, compound 9a effectively recovered the learning and memory impairment in scopolamine-induced amnesia model. |
| E-mail |
ohmyboko@naver.com |
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123rd General Meeting of the KCS