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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-408 |
| Subject |
A Retro-biosynthetic Accelerated Approach to Finding Novel Synthetic Scaffolds of Hit to Lead Compounds |
| Authors |
Tara Man Kadayat, Sung Jin Cho*, Jungwook Chin*
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Korea
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| Abstract |
(Marine) Natural products have long been providing a reasonable ground for uncharted drug discovery. However, due to their intricate molecular frameworks and unexplored chemical synthetic arena, the access to secure them in an economically sound method through semi-synthesis, total synthesis or isolation is often fraught with difficulties. Herein, this study aims to provide a potential solution with respect to scale and concise chemical synthesis through the logic of “Retro-Biosynthetic Accelerated Approach”. Starting from the economically viable secondary metabolites or natural sources from micro/macro organisms that pertain privileged scaffolds, the adoption of well-established synthetic/biosynthetic methods could yield libraries of ‘high value’ drug-like lead compounds. This method easily extends on the conventional process of the drug discovery, such as identifying hit compounds to early stage of lead compounds, and new scientific findings are warranted. |
| E-mail |
kadayattaraman@dgmif.re.kr |
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123rd General Meeting of the KCS