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|
| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-382 |
| Subject |
Histidine-containing antimicrobial peptoids |
| Authors |
Minsang Kim, Jiwon Seo1,*
Department of Chemistry, Gwangju Institute of Science and Technology, Korea
1Gwangju Institute of Science and Technology, Korea
|
| Abstract |
Antimicrobial peptides (AMPs) are one of the promising antibacterial therapeutic agents, however, despite the activity against broad spectrum pathogens, several drawbacks such as salt sensitivity, rapid degradation, and cost problem are still remained as unresolved tasks. Interestingly, salt resistance of some AMPs from marine organisms was reported, and the marine AMPs have been actively investigated to figure out properties and mechanisms. Especially, clavanins, piscidin, and chrysophsins which are known as histidine-rich marine AMPs show salt resistance and broad range activity against bacteria. Peptoids, N-substituted glycine polymers, which maintain sequence specificity and resistance to protease have been used in drug discovery to overcome previously mentioned disadvantages of AMPs. In this study, we designed and synthesized antimicrobial peptoid library which contained Nhis, N-(methylimidazole) glycine that mimics histidine. The α-helicity of each peptoids were analyzed by circular dichroism spectroscopy. The antimicrobial activity was determined by minimum inhibitory concentration (MIC) assay. Furthermore, these assays were performed in physiological salt conditions (150 mM NaCl) to examine salt resistance. |
| E-mail |
creamtic@gist.ac.kr |
|
123rd General Meeting of the KCS