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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-417 |
| Subject |
A novel cereblon modulator for targeted protein degradation |
| Authors |
Hyung Soo Kim, Jong Yeon Hwang1,*, Jae du Ha2, Sung Yun Cho2, Pilho Kim1, AhRa Go1, Yeong Uk Jeon3
organic chemistry, Korea University, Korea
1Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Korea
2WCI, Korea Research Institute of Chemical Technology, Korea
3pharmacy, Sungkyunkwan University, Korea
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| Abstract |
Immunomodulatory drugs (IMiDs) exert anti-myeloma activity by binding to the protein cereblon
(CRBN) and subsequently degrading IKZF1/3. We design and synthesize a novel IMiD analog TD-106 that induces the degradation of IKZF1/3 and inhibits the proliferation of multiple myeloma cells in vitro as well as in vivo. These results, therefore, firmly suggest that the newly synthesized IMiD analog, TD-106, is a novel CRBN modulator that can be used for targeted protein degradation. |
| E-mail |
hs813346@gmail.com |
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123rd General Meeting of the KCS