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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-421 |
| Subject |
Studies of secondary metabolites isolated from Korean mushroom |
| Authors |
Seon-Jun Choi, Young Seok Kim1, Sang Il Jeon1, Jungyeob Ham*
Natural Products Research, Korea Institute of Science and Technology, Korea
1Department of Chemistry, Gangneung-Wonju National University, Korea
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| Abstract |
To investigate the biological activity of various natural products derived from mushrooms, this study selected Suillus granulatus of Gangwon-do wild mushrooms, isolated the components and studied its chemical structure and biological activity. The methanol extract of Suillus granulatus was fractionated according to the polarity, and the ethyl acetate layer was selected and divided by reverse phase column and size exclusion chromatography. Suillusin and new substance suillusin B and C were isolated from M2 fraction. Suillusin had an insufficient effect on biological activity in the previous reports, and it is an edible mushroom that has lower toxicity. As a result of measurement of a new activity on lung cancer metastasis, it had an inhibitory effect on the EMT phenomenon of lung cancer cell (A546 cell) by TGF beta. As a result of measurement of the activities of suillusin B and suillusi C, too, their cytotoxicity was low, and the inhibitory effect on lung cancer metastasis was higher in suillusin B than suillusin and suillusin C. Suillus granulatus had an inhibitory effect on lung cancer metastasis as an edible mushroom with low cytotoxicity. It is expected that it would have a less side effect and wider value of use since it has low cytotoxicity. |
| E-mail |
117045@kist.re.kr |
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123rd General Meeting of the KCS