|
|
| Type |
Symposium |
| Area |
Analytical Technologies to Improve Human Health |
| Room No. |
Room 202 |
| Time |
FRI 15:45-16:10 |
| Code |
ANAL2-4 |
| Subject |
Mass spectrometric approaches toward clinical proteomics |
| Authors |
Jin Young Kim
Biomedical Omics Research Group, Korea Basic Science Institute, Korea |
| Abstract |
In proteomics aiming the biomarker discovery and development, mass spectrometer (MS) is an important analytical tool and is increasingly used for the investigation of clinical samples. Recent advances in protein or peptide separation and identification techniques have significantly improved proteomic approaches, leading to increase analytical performances such as specificity, sensitivity, throughput and robustness required for the successful clinical applications. In here, we will present the MS approaches and successes we have attempted to improve the analytical performance. There is mainly focused on MS based glycoproteomics including PRM-MS method combined with immunoprecipitation for the direct monitoring of glycopeptide targets in low abundant from serum and the high temperature LC-MS method for the enhanced separation of glyopeptide isomers. |
| E-mail |
jinyoung@kbsi.re.kr |
|
123rd General Meeting of the KCS