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Type |
Award Lecture in Division |
Area |
Current Trends in Organic Chemistry Ⅰ: Synthetic Methodology and Application |
Room No. |
Room 301+302 |
Time |
THU 15:40-16:10 |
Code |
ORGN1-1 |
Subject |
Development of New Catalytic Transformations: Efficient and Selective Construction of Various N-Heterocycles |
Authors |
So Won Youn Center for New Directions in Organic Synthesis, Department of Chemistry, Hanyang University, Korea |
Abstract |
Our research group has been interested in the development of new and efficient catalytic synthetic methods. Especially, we have been making efforts to develop effective one-pot protocols by using metal catalysts for heterocyclic synthesis. Since complicated molecules can be directly constructed from readily available starting materials under relatively mild conditions in an unprecedented manner, the direct and selective C-H bond functionalization plays a crucial role in preparing a wide range of biologically and physically important organic molecules, providing significant advantages over traditional synthetic methods. Moreover, one-pot reactions that involve a sequence of chemical transformations in a single flask are much desired as a powerful tool for the construction of various complex molecules from simple starting materials.
In this presentation, our recent discovery of several efficient Pd-catalyzed transformations will be described. These synthetic methods provided mild, simple, and efficient routes with high regio- and/or stereoselectivities to valuable N-heterocycles such as indoles, carbazoles, and isoindolinones which are important motifs in bioactive natural products, pharmaceuticals, and other functional molecules.
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E-mail |
sowony73@hanyang.ac.kr |
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