123rd General Meeting of the KCS

Type Award Lecture in Division
Area Current Trends in Organic Chemistry Ⅰ: Synthetic Methodology and Application
Room No. Room 301+302
Time THU 15:40-16:10
Code ORGN1-1
Subject Development of New Catalytic Transformations: Efficient and Selective Construction of Various N-Heterocycles
Authors So Won Youn
Center for New Directions in Organic Synthesis, Department of Chemistry, Hanyang University, Korea
Abstract Our research group has been interested in the development of new and efficient catalytic synthetic methods. Especially, we have been making efforts to develop effective one-pot protocols by using metal catalysts for heterocyclic synthesis. Since complicated molecules can be directly constructed from readily available starting materials under relatively mild conditions in an unprecedented manner, the direct and selective C-H bond functionalization plays a crucial role in preparing a wide range of biologically and physically important organic molecules, providing significant advantages over traditional synthetic methods. Moreover, one-pot reactions that involve a sequence of chemical transformations in a single flask are much desired as a powerful tool for the construction of various complex molecules from simple starting materials.
In this presentation, our recent discovery of several efficient Pd-catalyzed transformations will be described. These synthetic methods provided mild, simple, and efficient routes with high regio- and/or stereoselectivities to valuable N-heterocycles such as indoles, carbazoles, and isoindolinones which are important motifs in bioactive natural products, pharmaceuticals, and other functional molecules.
E-mail sowony73@hanyang.ac.kr