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| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Analytical Chemists II |
| Room No. |
Room 202 |
| Time |
FRI 10:12-10:16 |
| Code |
ANAL2.O-19 |
| Subject |
Metabolomic analysis of human blood associated with ambient particulate matter in air pollution |
| Authors |
Seoyoung Jang, Geum-Sook Hwang*
Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Korea
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| Abstract |
Ambient particulate matter (PM) has became the major environmental risk factors in Korea, and exposure to PM is associated with adverse health effects on human. The objective of this study was to assess the alteration in response to environmental exposure and to investigate the association between levels of metabolite identified in human whole blood samples and PM with a diameter 2.5-10 µm(PM10).
In this study, we analyzed human whole blood from 457 Koreans using 1H-NMR spectroscopy. The concentration of PM10 was used in multivariate linear regression model adjusted for age, sex, BMI, and smoking status. We found that PM10 was significantly related to energy metabolism such as lactate, pyruvate, glucose, and fumarate.
This approach can be a novel tool to identify potential biomarkers for predicting exposure of pollutants like PM10 and to assess the impacts of environmental pollution on human metabolism.
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| E-mail |
chemomi@hotmail.co.kr |
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123rd General Meeting of the KCS