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2-D Nanoparticles Intercalated with Anticacer Drugs for Target Delivery

Submission Date :
8 / 29 / 2008 , 17 : 39 : 06
Abstract Number :
Presenting Type:
Presenting Area :
재료화학 - Multi-Functional Hybrid Materials I
Authors :
지능형나노-바이오소재연구센터 화학 나노과학과, 이화여자대학교, Korea
Assigned Code :
목20B3심 Assigend Code Guideline
Presenting Time :
목 15시 : 20분
Biomolecular-inorganic nanohybrids with two different functions, one from inorganic moiety and the other from biological or organic one, have been realized for drug delivery system. Recently we have developed a new hybrid systems consisting of anticancer drugs like methotrexate (MTX) or 5-Fluorouracil (5-FU) and two-dimensional inorganic compound like layered double hydroxide (LDH) as a drug delivery carrier. To the best of our knowledge, such an inorganic vector is completely different from conventionally developed ones such as viral-based, naked DNA, cationic liposomes and biodegradable polymers, those which are limited in certain cases of applications due to their toxicity, immunogenecity, poor integration, and etc. But the above mentioned problems can be overcome by synthesizing inorganic nanovehicles properly with non-toxic metal ions having biological compatibility. Moreover, we found that LDH could protect chemically fragile anticancer drugs very efficiently under harsh experimental conditions. In addition, we have clearly demonstrated that the intercellular mechanism and pathways of LDH nanoparticles are principally related to clathrin mediated endocytosis. As the typical examples of inorganic drug delivery system, MTX-LDH and 5-FU-LDH nanohybrids will be demonstrated not only in-vivo but also in vitro.