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  • 09월 12일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제110회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Physical Property Analysis of Phospholipid Surfactant Layers Based on the Microfluidic Device: the Effect of Ozonolysis on the Model Surfactant Layers

2012년 9월 5일 12시 22분 38초
ANAL.P-703 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 17일 (수요일) 16:00~19:00
저자 및
최태수, 김준곤
포항공과대학교 화학과, Korea
In the biological system, one of the representative air-liquid interfaces is the pulmonary surfactant (PS) system which comprises mixtures of phospholipids and proteins. The PS system participates in the breath cycle by controlling the surface tension and the fluidity of the interface in alveolar sacs. The present study provides the application of the microfluidic bubble generator for interfacial chemical reactions and resulted functional alteration studies related to PS system. Previously, we have found that only unsaturated phospholipids in the surfactant layer, which comprises saturated and unsaturated phospholipids, undergoes oxidation reaction by ozone. Then, the oxidized unsaturated phospholipid products dissolve into the bulk phase, leaving only saturated phospholipid at the air-liquid interface (J. Phys. Chem. B, 2010, 114, 9496). In the present study, we describe the alteration of physical properties such as oscillatory behavior, of the interfacial layer, which comprises saturated dipalmitoylphosphatidylcholine (DPPC) and unsaturated 1-palmitoyl-2-oleoylphosphatidylglycerol (POPG), under oxidative stress by ozone. Size and formation time changes of micro-bubbles by interfacial reaction by ozone are also described. For example, the model surfactant layer with ozone exhibits ~28% higher elasticity and takes five times longer period for the formation of bubble compared with when air is applied for bubble generation. The study reports on the application of micro-bubble generator for the investigation of air-liquid interfacial chemistry and physics which is distinct from conventional encapsulating applications of micro-bubbles.