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  • 02월 19일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제119회 대한화학회 학술발표회, 총회 및 기기전시회 안내 High-density Cisplatin-encapsulated Polymeric Nanostructures with Robust Stability and pH-sensitive Cargo-releasing Properties

2017년 2월 16일 11시 45분 18초
MAT.P-472 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 21일 (금요일) 13:00~14:30
저자 및
가톨릭대학교 화학과, Korea
Over the past decades, biocompatible polymers have been proposed as a delivery platform for the improved aqueous solubility and reduced off-target toxicity for small-molecule drugs, allowing for the selected delivery to the disease sites. Although such delivery systems have been demonstrated to possess great potential to decrease the toxic side effects often associated with conventional chemotherapy, successes have been limited due in part to the limited colloidal stability and specific triggers to release the encapsulated drug molecules under predefined biochemical condition. To overcome these challenges, we have developed two strategies based on the chemically modified natural polysaccharides such as chitosan and artificial synthetic block-copolymers for polymeric excipients to encapsulate cisplatin pharmacophore (PtII) as a model drug. For stability enhancement and inorganic drug-conjugation, native chitosan was modified with small poly(ethylene glycol) and malonic acid, which was then subjected to bind the aqua derivatives of PtII species. As a synthetic polymer-based platform, a series of poly(ethylene glycol)-b-poly(acrylic acid) copolymers have been synthesized via nitroxide-mediated radical polymerization with chemically modified alkoxyamine initiator, which was then employed to incorporate the chemotherapeutic PtII compounds. Both approaches lead to the formation of self-assembled nanoscale structures in aqueous solution, which possess the grafted polymer chains cross-linked via PtII-coordination and hydrophobic interactions, allowing for the enhanced colloidal stability and pH-sensitive reversible release of PtII species. The physicochemical properties of the resulting materials will be demonstrated.