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02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내
Optimization Study about Synthesis of Silicon Coated Gold Nanoparticles for Dual Imaging and Dual Therapy
2018년 2월 7일 16시 12분 32초
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금 10시 : 45분
Analytical Chemistry -
Oral Presentation of Young Analytical Chemists II
, Jiwon Kim
, Hoeil Chung
, Youngbok Lee
Department of Bio-Nano Technology, Hanyang University, Korea
Department of Chemistry, Hanyang University, Korea
In this research, silicon coated gold nanoparticles (Au NPs@Si) for dual imaging and therapy were synthesized. Gold nanoparticles (Au NPs) can be used for Surface-Enhanced Raman Spectroscopy (SERS) substrates and thermal therapy for cancer as photo-thermal agents. And then, silicon (Si) can make an amplified signal by DNP, one of the hyperpolarization phenomena, so that it can be used for MR imaging probe and also drug delivery through pores. The Au NPs made by seeded growth method were coated with silica using stöber method. The thickness of the silica shell was adjusted by varying the amount of TEOS, and the scale was gradually increased to obtain sufficient amount for reduction. Silica coated gold nanoparticles were converted to Au NPs@Si by magnesiothermic reduction. Reduction process was proceeded using a closed reactor and the optimized conditions to obtain Au NPs coated with a high raio of silicon were found by varying the reduction temperature and time. It was confirmed that the silica shell was reduced to silicon by the observation of the crystallinity of silicon, and that the Au NPs remained after the reduction process through the TEM images. Au NPs@Si can give an amplificated Raman signals compared to the conventional signals by SERS effect and increase temperature when the laser is applied. Then fluorescent material can be loaded and released by Au NPs@Si to evaluate drug delivery efficiency and amplified signal by DNP can be used for MR imaging. Therefore, through these methods, the effectiveness of synthesized Au NPs@Si as probes for dual imaging and dual therapy for cancer diagnosis and therapy can be evaluated.
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