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  • 09월 03일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Time-Controlled Nanoscale Delivery System

2018년 8월 23일 12시 23분 18초
MAT.O-7 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 09시 : 42분
Material Chemisty - Oral Presentation of Young Material Chemists
저자 및
Jihyeon Park, SeoYeah Oh, Dongjun Kim1, Wonsik Lee, Geonho Kim, Jiwon Kim*
School of Integrated Technology, Yonsei University, Korea
1School of integrated technology, Yonsei University, Korea
Many reactions, especially in vivo, are time-dependent since reactants degrade or change over time. Therefore, delivering cargoes at desired time points and positions in nanoscale is necessary and injection at different time points is possible. However, it is difficult to spatio-temporally control the transmission of cargoes especially within short period time because they proceed with random walk motion. Thus, nanomotors – which the velocity can be controlled in nanoscale fluid systems – can be good candidate. Since controlling with two different external driving force on the same type of nanomotor is challenging to precisely control the velocity, herein, we designed two (or more) types of nanomotor which can travel at different speeds under the same applied stimuli. The nanomotors were composed of gold head – silver flexible filament – nickel tail encapsulated with N-isopropylacrylamide (NIPAm) based hydrogel. The difference in speed was controlled by adjusting the length of each compartment whereas the cargo releasing time was regulated by optimizing the thickness of encapsulating hydrogel. Our nanomotor based nanoscale delivery system can control the delivery time down to a few minutes, which can possibly increase the efficiency of multiple drugs or gene editing (where the cargoes easily degrade/denature) and also be used in molecular communications for transmitting information through (bio)materials. We believe the spatio-temporally controlled nanoscale delivery system will broaden the range of application areas of nanomaterials by enhancing the spatial and temporal accuracy in delivering cargoes in nanoscale.