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  • 09월 03일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Electospun Fibrous PCL and PLGA mats incorporated with AuRD for Photothermal theraphy

2018년 8월 23일 16시 44분 01초
MAT.O-10 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 10시 : 03분
Material Chemisty - Oral Presentation of Young Material Chemists
저자 및
Hojun Seo, Eunmi Im, Geondae Moon*
Korea Institute of Industrial Technology, Korea
Pthotothermal therapy (PTT) based on near-infrared (NIR) light has been attracting huge attention to replace conventional treatments for cancer therapy because of its minimal invasiveness and high selectivity. An irreversible damage can be done to tumor cells by using photothermal agents that can absorb NIR light and dissipate the absorbed energy to heat in the cells. Nevertheless, the treatment of only PTT is incapable of achieving satisfactory therapeutic effect because of heterogeneous distribution of heat generated within the tumor. In addition, survived cancer cells after the treatment can induce cancer metastasis or recurrence. In this presentation, we introduce new fibrous systems with photothermal agents designed from a combination of PTT and chemotherapy. The first system consists of polycaprolactone (PCL) including Au nanorods as a photothermal agent to demonstrate the optimal heat generation condition by changing the absorbed wavelength. The photothermal efficiency varies based on aspect ratio of Au nanorods showing different absorption efficiency. The second system contains poly(D,L-lactic-co-glycolic acid) (PLGA) hollow fibers encapsulating an anticancer drug in their core, accompanied by shell with Au nanorods to prevent a undesired passive release of the drug molecules. On exposure to NIR light, the photothermal agent entrapped in the shell generates heat to raise the local temperature of the fibers. Above a glass transition (Tg), the polymer chains will be mobile, which enlarges free volume in size within the shell and consequently results in a rapid release of the drug. The segment of the chains will freeze by the inactivity of the photothermal agent when NIR light is turned off, which terminates the drug release. A repeated and accurate release of the drug is possible in an on-demand manner through the segmental switching of the polymer chains in response to the on–off operation of NIR light. Therefore, the anticancer activity can be enhanced by the hyperthermia effect from the photothermal agent.