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125th General Meeting of Korean Chemical Society Polycyclic Compounds in Drug Discovery

Submission Date :
6 / 15 / 2020 , 17 : 54 : 48
Abstract Number :
Presenting Type:
Award Lecture in Division
Presenting Area :
Organic Chemistry - Current Trends in Medicinal Chemistry & Chemical Biology
Authors :
Jung-Nyoung Heo
Organic Chemistry, Korea Research Institute of Chemical Technology, Korea
Assigned Code :
ORGN3-5 Assigend Code Guideline
Presenting Time :
TUE, 16 : 30
In an area of organic synthesis and medicinal chemistry, exploration of practical and efficient synthetic methods provides great interests to the search of bioactive compounds, natural products, and pharmaceutical agents. In recent years, our laboratory have been particularly interested in the development of new one-pot synthetic approaches for rapid, facile, and economic construction of a number of biologically interesting natural products and pharmaceuticla compounds. During this process, research efforts from our group have focused on the discovery of new anticancer agents with specific molecular targets. In particular, we have discovered STP1002 as a potent, first-in-class tankyrase inhibitor that expresses anticancer activity against colon cancer.