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Inorganic Nanoparticles and Hollow Spheres for DNA and RNA Delivery

2007년 8월 8일 15시 32분 24초
목26B5심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 15시 : 00분
100회 기념 NT 및 초분자심포지엄
저자 및
G..Q. Max Lu
ARC Centre of Excellence for Functional Nanomaterials, University of Queensland, Australia,
This paper presents an overview of our recent research on two classes of nanoparticles and nanoporous materials, from their synthesis to characterization and to potential applications. LDH nanoparticles have been made into stable suspension in aqueous solution and used for delivery of drug and DNA molecules into mammalian cells. The key questions of the effects of particle properties and transfection mechanisms and efficiency will be discussed. Another type of nanomaterials is hollow spheres of mesoporous silica which has been synthesized using a new dual templating method. Such hollow spheres are being tested for drug delivery and enzyme immobilisation. The properties of such hollow spheres such as large pore volume in the core, and tunable pore size and mesostructure in the wall are very promising for storage and release of more than one drug molecules, which will lead to more effective cancer chemotherapies. The rich surface chemistry of the hollow spheres render them easy surface functionalisation abilities for conjugation of antibodies or other biomarkers, a promising property for target delivery of loaded drug or DNA molecules.