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마감일 2017-04-30 

Title: Medicinal Chemistry Postdoctoral Fellowship at NCI, NIH


A postdoctoral fellowship in the field of medicinal chemistry is immediately available to carry out structure-based drug design and hit-to-lead optimization on several promising hits against polo-like kinase 1 (Plk1).  Plk1 is an attractive anti-cancer therapeutic target, whose upregulated activity is tightly associated with aggressiveness and poor prognosis for a wide spectrum of human cancers. We performed high throughput screening campaigns at the at the National Center for Advancing Translational Sciences (NCATS) (, and isolated a new class of several anti-Plk1 small molecule compounds, whose cocrystal structures have been determined lately. In an effort to discover novel Plk1-targeted anti-cancer therapeutic agents, we have developed an NCI’s multifaceted collaboration project by bringing together various expertise, including medicinal chemistry optimization, X-ray crystallography, in silico modeling, pharmacokinetics/pharmacodynamics, and mouse tumorigenesis studies. Once appointed, the fellow will primarily work in the synthetic chemistry lab at NCATS under the direct guidance of Dr. David Maloney (, the medicinal chemistry leader at NCATS, and Dr. Kyung Lee ( in the Laboratory of Metabolism, NCI, and will have an opportunity to interact with other collaboration teams involved in this interdisciplinary project.

Applicants should have (or expected to receive) a Ph.D. or its equivalent at the time of joining the lab or have achieved the degree less than 3 years ago. Fellows who have an expertise in medicinal chemistry optimization of small molecule inhibitors or X-ray crystallography are encouraged to apply. Salary starts at $51,900 with full health insurance for fellows with no prior postdoctoral training.

To apply, please send CV and three names of references to Dr. Kyung Lee (


Employer Name: National Cancer Institute, NIH.

Position Location: 9000 Rockville Pike, Bethesda, MD 20892, U. S. A.


Selected Publications:

1) Yun, S. -M. et al., 2009. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat. Str. & Mol. Biol. 16:876.

2) Liu, F. et al., 2011. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.  Nat. Chem. Biol. 7:595.

3) Liu, F. et al., 2012. Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using Oxime-based diversification. ACS Chem. Biol. 7:805.

4) Liu, F. et al., 2012. Peptoid-peptide hybrid ligands targeting the polo-box domain of polo-like kinase 1. Chembiochem. 13:1291.

5) Qian W. -J. et al., 2012. Non-proteinogenic amino            acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo-box domain (PBD) of polo-like kinase 1 (Plk1). Bioorg Med Chem Lett. 22:7306.

6) Qian, W. -J. et al., 2013. Effects on Polo-like Kinase 1 Polo-box Domain Binding Affinities of Peptides Incurred by Structural Variation at the Phosphoamino Acid Position. Bioorg. & Med. Chem. 21: 3996.

7) Qian, W. -J. et al., 2014. Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells. Biopolymers 102:444.

8) Qian, W. -J. et al., 2015. Neighbor-directed Histidine N(τ)–Alkylation: A Route to Imidazolium-containing Phosphopeptide Macrocycles. Biopolymers, 104:663

9) Lee, K. S. et al., 2015. Recent advances and new strategies in targeting Plk1 for anticancer therapy. Trends in Pharmacological Sciences. 36:858 (review).

마감일 제목 이름 날짜 조회 수
2017-07-03  출연연 : 한국화학연구원 화학소재솔루션센터 연구학생(석박사 과정) 및 인턴직원 모집 조태연 2017.05.31 432
2017-07-31  출연연 : 국립암센터 구조생화학 과제 연구원 및 PostDoc 이병일 2017.05.23 380
2017-04-30  출연연 : NIH Medicinal Chemistry Postdoctoral Fellowship for Anti-cancer Drug Discovery file Kyung Sang Lee 2017.02.14 562
2017-03-21  출연연 : Call for Applications for Associate Director Positions of "Center for Quantum Nanoscience" in the Institute for Basic Science (IBS) 이비 2017.02.07 5847
2017-01-18  출연연 : 표준연 나노바이오측정센터 Post-doc 모집 이태걸 2017.01.12 558
2016-11-11  출연연 : 한국교육과정평가원 직원 모집(연구직) file KCS 2016.11.07 999
2016-08-31  출연연 : 한국화학연구원 2016년 하반기 정규직 채용공고 김석환 2016.07.28 1378
2016-07-10  출연연 : 한국과학기술연구원 천연물연구소 석사인턴 및 Post-doc 연구원 모집 김태정 2016.07.04 1119
2016-05-20  출연연 : 한국과학기술연구원 (KIST) 테라그노시스연구단 박사후연구원 모집 김소연 2016.04.20 1165
2016-04-04  출연연 : 한국과학창의재단 2016년 상반기 위촉직(일반, 장애인), 청년인턴 채용 file 류춘렬 2016.03.30 993
2016-04-08  출연연 : 2016년도 제 1차 정규직 채용 공고 file 김강훈 2016.03.28 1333
2016-04-21  출연연 : [한국화학연구원] 2016년 상반기 정규직 직원(연구분야) 채용 공고 김석환 2016.03.23 1198
2016-03-30  출연연 : 한국기초과학지원연구원(KBSI)서울서부센터 DRC 석박사과정 모집 file 김유라 2016.03.22 1102
2016-04-29  출연연 : 한국생명공학연구원 유기화학 전공 박사후연구원 모집 (나노메디슨 연구) 김윤경 2016.03.09 1043
2016-03-31  출연연 : 한국해양과학기술원-UST 대학원생 및 인턴연구원 모집 (천연물화학/유기합성 전공) 이지훈 2016.03.02 1086
2016-03-31  출연연 : 한국원자력연구원 양성자가속기연구센터 석사/박사후연구원 모집 김계령 2016.02.15 1076
2016-03-31  출연연 : KIST chemical biology 연구실 석박사과정 모집 이준석 2016.01.28 1181
2016-01-29  출연연 : Argonne National Laboratory, Postdoc position – Detector Materials file 정덕영 2016.01.07 1046
2016-01-29  출연연 : Argonne National Laboratory - postdoc position - superconductor file 정덕영 2016.01.07 961
2016-01-10  출연연 : 한국생명공학연구원 유기합성전공 박사후연구원 모집 유수연 2015.11.27 975