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화학업체와 학교 및 기관의 구인/구직 소식을 살펴보실 수 있습니다.
게시물 등록에 대한 문의사항은 오민영 myoh@kcsnet.or.kr 메일로 해주시기 바랍니다.

※ 게시물 등록절차 : 로그인후 글 작성(비공개) 담당자에게 자동통보 확인 후 게시물승인(공개)
※ 주의사항1 : 업체명이 없는 (예:헤드헌팅) 등록 글은 통보 없이 삭제 처리됩니다.
※ 주의사항2 : 게시물 승인이후 수정 하실 경우 다시 비공개로 전환됩니다.

마감일 2017-04-30 

Title: Medicinal Chemistry Postdoctoral Fellowship at NCI, NIH

 

A postdoctoral fellowship in the field of medicinal chemistry is immediately available to carry out structure-based drug design and hit-to-lead optimization on several promising hits against polo-like kinase 1 (Plk1).  Plk1 is an attractive anti-cancer therapeutic target, whose upregulated activity is tightly associated with aggressiveness and poor prognosis for a wide spectrum of human cancers. We performed high throughput screening campaigns at the at the National Center for Advancing Translational Sciences (NCATS) (https://ncats.nih.gov/), and isolated a new class of several anti-Plk1 small molecule compounds, whose cocrystal structures have been determined lately. In an effort to discover novel Plk1-targeted anti-cancer therapeutic agents, we have developed an NCI’s multifaceted collaboration project by bringing together various expertise, including medicinal chemistry optimization, X-ray crystallography, in silico modeling, pharmacokinetics/pharmacodynamics, and mouse tumorigenesis studies. Once appointed, the fellow will primarily work in the synthetic chemistry lab at NCATS under the direct guidance of Dr. David Maloney (https://ncats.nih.gov/staff/maloneyd), the medicinal chemistry leader at NCATS, and Dr. Kyung Lee (https://ccr.cancer.gov/Laboratory-of-Metabolism/kyung-s-lee) in the Laboratory of Metabolism, NCI, and will have an opportunity to interact with other collaboration teams involved in this interdisciplinary project.


Applicants should have (or expected to receive) a Ph.D. or its equivalent at the time of joining the lab or have achieved the degree less than 3 years ago. Fellows who have an expertise in medicinal chemistry optimization of small molecule inhibitors or X-ray crystallography are encouraged to apply. Salary starts at $51,900 with full health insurance for fellows with no prior postdoctoral training.

To apply, please send CV and three names of references to Dr. Kyung Lee (kyunglee@mail.nih.gov)

 

Employer Name: National Cancer Institute, NIH.

Position Location: 9000 Rockville Pike, Bethesda, MD 20892, U. S. A.

 

Selected Publications:

1) Yun, S. -M. et al., 2009. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat. Str. & Mol. Biol. 16:876.

2) Liu, F. et al., 2011. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.  Nat. Chem. Biol. 7:595.

3) Liu, F. et al., 2012. Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using Oxime-based diversification. ACS Chem. Biol. 7:805.

4) Liu, F. et al., 2012. Peptoid-peptide hybrid ligands targeting the polo-box domain of polo-like kinase 1. Chembiochem. 13:1291.

5) Qian W. -J. et al., 2012. Non-proteinogenic amino            acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo-box domain (PBD) of polo-like kinase 1 (Plk1). Bioorg Med Chem Lett. 22:7306.

6) Qian, W. -J. et al., 2013. Effects on Polo-like Kinase 1 Polo-box Domain Binding Affinities of Peptides Incurred by Structural Variation at the Phosphoamino Acid Position. Bioorg. & Med. Chem. 21: 3996.

7) Qian, W. -J. et al., 2014. Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells. Biopolymers 102:444.

8) Qian, W. -J. et al., 2015. Neighbor-directed Histidine N(τ)–Alkylation: A Route to Imidazolium-containing Phosphopeptide Macrocycles. Biopolymers, 104:663

9) Lee, K. S. et al., 2015. Recent advances and new strategies in targeting Plk1 for anticancer therapy. Trends in Pharmacological Sciences. 36:858 (review).

마감일 제목 이름 날짜 조회 수
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2016-05-20  출연연 : 한국과학기술연구원 (KIST) 테라그노시스연구단 박사후연구원 모집 김소연 2016.04.20 992
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