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  • 02월 23일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Luminescence chemosensors for ionic recognition

2009년 3월 3일 11시 10분 14초
목13K1분념 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 13시 : 30분
유기화학 - New Development in Organic Chemistry (Reaction, Methodology, and Synthesis)
저자 및
고려대학교 화학과, Korea

Over the years, we have paid attention to designing a series of organic molecules acting chromo and fluorogenic behaviors for specific target ions. A novel coumarin-based fluorogenic probe bearing the 2-picolyl unit was developed as a fluorescent chemosensor with high selectivity and suitable affinity in biological system toward Cu2+ over other cations tested. The fluorescence on-off mechanism was studied by femtosecond time-resolved fluorescence (TRF) upconversion technique and ab initio calculations. The receptor can be applied to the monitoring of Cu2+ ion in aqueous solution with a pH span 4-10. To confirm the suitability of the ligand for biological applications, we also employed it for the fluorescence detection of the changes of intracellular Cu2+ in cultured cells. The results indicate that the ligand should be useful for the fluorescence microscopic imaging and the study on the biological functions of Cu2+.

The electrochemiluminescence (ECL) efficiency and radical stability of pyrene, a poor ECL luminophore, are markedly improved as the number of peripheral multidonor units increased in a series of compounds. Photophysical and electrochemical studies and theoretical calculations have contributed to the understanding of the ECL enhancement, which is a step forward in the development of new light-emitting materials.