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  • 09월 09일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제106회 대한화학회 학술발표회, 총회 및 기기전시회 Chaos vs. Control: The Chemistry of Large Molecular Systems in Water

2010년 9월 15일 10시 13분 30초
ORGN1-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 16시 : 10분
유기화학 - 분자인식화학 국제심포지엄
저자 및
Brent L. Iverson
The University of Texas at Austin, U.S.A., United States
Several projects will be described that span the interface of chemistry and biology. On the synthetic chemistry side, our work revolves around the use of complementary aromatic donor-acceptor interactions in aqueous solution to control folding and assembly of complex molecular systems. Complementary aromatic donor-acceptor stacking units offer the advantages of a strong hydrophobic effect driving force in water combined with recognition sufficient to organize flexible molecular systems. Recent work has centered on amphiphilic folding molecules that undergo an irreversible conformational change to enable the creation of the first abiotic highly ordered aggregate reminiscent of amyloid formation, a process that is indicated in a growing number of neurodegenerative diseases, most notably Alzheimer’s disease. In addition, we continue to develop a series of molecules that bind to specific sites on double-stranded DNA through a novel mode of interaction referred to as threading polyintercalation. On the molecular biology front we have developed several technologies that enable us to engineer desirable properties into proteins of practical interest, including antibodies and enzymes intended for use as therapies. For example, we have engineered an antibody that can prevent and cure anthrax. Most recently, we have been engineering enzymes such as proteases (enzymes that cleave other proteins) in an effort to create catalytic therapies to treat cancer or inflammatory disease.