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학술발표회초록보기

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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Use of β-silyl styrene in the cycloaddition reaction with 3,5-dibromo-2-pyrone for the total synthesis of (±)-pancratistatin

등록일
2011년 8월 1일 12시 49분 56초
접수번호
1025
발표코드
Ⅲ-ORGN.P-185 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
정용근, 조천규
한양대학교 화학과, Korea
Pancratistatin is a natural compound that was initially extracted from Spider Lily a Hawaiian native plant that belongs to the family of Amaryllidaceae. It has been shown to have potent anti-cancer activities and selectively induce apoptosis in several human cancer cell lines. The promising biological activity and natural paucity has made pancratistatin an interesting target for total synthesis. Ever since the first total synthesis reported by Danishefsky and coworkers in 1989, many research groups around the world have presented novel strategies and routes to this natural compound. A few years ago, we have reported the first total synthesis of trans-dihydronarciclasine, very close congenor of pancratistatin, by utilizing Diels-Alder reaction of 3,5-dibromo-2-pyrone. We have further envisioned the use of vinylsilane as dienophile would provide a handle for the easy installation of the hydroxy group. Herein, we report the successful realization of our concept which allowed the total synthesis of (±)-pancratistatin.

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