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제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Amphiphilic α-helical peptides that induce apoptosis through interaction with Bcl-2

등록일
2011년 8월 1일 15시 04분 43초
접수번호
1187
발표코드
Ⅰ-BIO.P-208 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
허연, 유재훈
서울대학교 화학교육과, Korea
Bcl-2 is one of the pro-survival factors of Bcl-xl family that inhibits apoptosis signaling by interacting with Bak or Bax protein. If it is over-expressed, pro-survival Bcl-2 proteins can lead to non-apoptotic cancerous cells. Thus, a blockage of interaction of Bcl-2 with counter-part proteins could reduce survival factors and finally induce apoptosis. We thought that a simple α-helical amphiphilic peptide could bind to Bcl-2 and induce apoptosis. A tailor-made strategy was applied to find out the strong and selective peptide against Bcl-2. After several rounds of selection, peptide 6Aad8 was chosen as the best binder against Bcl-2. The peptide, indeed, produced many apoptotic signals, affording the cell pro-apototic and eventually mortal at nanomolar concentration (EC50 = 50 nM).

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