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제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 In Vitro Developmental Acceleration of Hippocampal Neurons on Nanostructures of Self-Assembled Glass Beads in Filopodium-Size Ranges

2011년 8월 1일 15시 38분 50초
Ⅳ-INOR.P-88 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 <발표Ⅳ>
저자 및
최성은, 강경태1, 장희수, 최인성1, 남윤기2, 이진석
숙명여자대학교 화학과, Korea
1KAIST 화학과, Korea
2KAIST 바이오및뇌공학과, Korea
Nervous systems are composed of microstructured scaffolds with three-dimensional nanofeatured textures. These texturesenable the systems to give nanometer-scaled physical cues to the overlying cells, along with biochemical cues. However, it is practically very difficult to investigate the topographical environments in vivo in the biological systems and/or to mimic them precisely in vitro. Recently, the acceleration of neuronal development and neurite outgrowth was revealed by recent works from us on various types of nanotopographies. Concrete understanding of the topographical effects on neuronal development and neurite outgrowth would be intensively beneficial for the biomedical applications. However, there were few systematic studies about these nanotopographical effects on neuronal developments in a feature size-dependent manner. Herein, we report a nanoscale-resolved study of nanotopographical effects on development of hippocampal neurons. In this study, we use substrates with packed glass beads by rubbing method for generating highly periodic nanotopographies with various sizes. We found that acceleration of neuritogenesis appeared only on the beads larger than 200 nm in diameter, and observed that filopodial thickness was comparable with this scale. This study is expected to be essential to elucidate the nanotopographical effect on neuronal development.