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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Flora Genesis System : Chemical profiling System of Natural Product

2011년 8월 1일 16시 04분 05초
Ⅰ-BIO.P-215 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 <발표Ⅰ>
저자 및
이창준, 강신문1, 장병하2, 박규환3, 김현식4, 유종신5, 노경태6
(사)분자설계연구소 분자정보팀, Korea
1(사)분자설계연구소 신약개발, Korea
2(사)분자설계연구소, Korea
3한국기초과학지원연구원 질량분석개발팀, Korea
4한국기초과학지원연구원 질량분석기개발팀, Korea
5한국기초과학지원연구원 연구장비개발부, Korea
6연세대학교 생명공학과, Korea
We develop a system for profiling chemicals in plants, which we named 'Flora Genesis System' (FG system). There are two major parts: one for experimental data analysis, and the other for computational counterpart. Experimentally obtained data from MS, NMR, LC and GC are forwarded to computational analysis, which consists of Molecular Formula Generation, Theoretical Peak Generation, Searching Database, Comparing Profiles and Prediction System (Activity, Toxicity, ...). This poster shows how to compare profiles of fresh ginseng, red ginseng and camphor ginseng, using 15T FT-ICR MS with the globally highest level of resolution and accuracy. Thanks to its high performance, a lot of chemicals from plant sample can be analyzed simultaneously. Our system can quickly analyze the results from the 15T FT-ICR MS. The highly efficient mass spectrometer enables a rapid-concurrent analysis of multi-chemicals nowadays. Flora Genesis has improved the speed of analysis providing the possibilities to excavate the diversity of highly valuable chemicals, such as extracts containing chemicals with pharmacologic activity, cover ingredients of origin, and main components of different efficacies, etc and to quickly explore candidates of New Chemical Entity. Using this advanced analysis system, we can anticipate an academic ripple effect on developing the new frontier about state-of-the-art field of mixture analysis and a financial ripple on commercializing the excavated high value chemicals in various fields, such as food, beverage, cosmetics, medicinal herbs and metabolome, etc.