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제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Hair steroid signatures explain the racial differences in male-pattern baldness

2011년 8월 1일 16시 04분 30초
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목 15시 : 25분
분석화학 - Emerging Analytical Techniques Based on -Omics
저자 및
최만호, 정봉철
한국과학기술연구원/미래융합기술연구본부, Korea
Pathological and epidemiological studies show racial variations in the metabolic patterns of testosterone (T) and dihydrotestosterone (DHT) as well as the activity of their metabolic enzyme 5α-reductase. As the incidence of male-pattern baldness (MPB) varies between countries and ethnic groups, the concentrations of hair steroids in Koreans were compared with Caucasians with and without hair-loss. Twelve steroids in the vertex hair were examined by gas chromatography-mass spectrometry-based steroid signatures. The MPB related androgens including T, DHT and Epi-T were up-regulated in both Korean groups, whereas pregnenolone was significantly higher in both Caucasian groups. Based on the higher incidence of MPB in Caucasians, the higher levels of DHT in the Korean populations suggest that hair-loss is not only affected by 5α-reductase, but the affinity of androgen receptors. Regarding the metabolic ratios, 5α-reductase and 3β-hydroxysteroid dehydrogenase were up-regulated in Caucasians (P < 0.03) and Koreans (P < 0.006), respectively, and their activities were associated with androstenedione, which is the immediate precursor of T. This suggests racial differences within hair steroids and steroid metabolic enzymes can explain the clinically observed differences in the endocrinology of MPB between racial groups.