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학술발표회초록보기

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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Mimicking a biological cellular structure with incorporation of interior organelles and protein cytoskeletal network in the cytoplasm

등록일
2011년 8월 1일 16시 08분 05초
접수번호
1315
발표코드
Ⅰ-BIO.P-217 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
박수진, 이두호, 신관우1
서강대학교 화학과, Korea
1서강대학교 화학과 및 바이오융합과정, Korea
A giant unilamellar vesicle (GUV) has received much attention recently because they, as a biological cell mimic in size and shape, can be utilized as a biological mimics. Up to now, many researchers have reported the dynamics and physical properties of GUV, for examples, dynamics of GUV with shear elasticity, or lipid phase behaviors of GUV, etc. However most biological cells contain organelles, and cytoskeletal network in their cytoplasm, and it is not hard to expect that the physical properties of GUV will be greatly affected when a cellular vesicles contains complex sub-cellular structures (organelles and protein networks) in the cytoplasm. Initially, we mimicked various non-spherical structures of cellular organelle mimics (tadpole, snowman, dumbbell, etc) by varying major membrane components. We could successfully inject the organelle mimics into a GUV. Furthermore, we introduced the collagen-mediated fibers into the cytoplasm, resulting in the fiber network in the inner volume of GUVs. We then could study how the mechanical/physical properties of GUV membranes were affected with the incorporation of interior-organelles and protein-cytoskeletal network.

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