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학술발표회초록보기

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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Adsorption behavior and fibrillo-genesis of fibronectin on negatively charged-patterned surfaces

등록일
2011년 8월 1일 16시 20분 37초
접수번호
1332
발표코드
Ⅰ-BIO.P-219 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
Yalda Hozhbari Pooladi Nezhad
서강대학교 화학과, Korea
Fibronectin(FN) is a high molecular extracellular glycoprotein that is found as globular or extended fibril structures depending on biological conditions Which can be dimer or polymer . When it converts to the fibril structure at the cellular membrane surface FNs play a critical role in angiogenesis, differentiation, proliferation, migration, wound healing and tissue repairing. Previously, we found that FN can selectively adsorb onto a highly charged surface, and FNs form a micro-scaled stretched fiber network. In this study, we are interested in finding essential parameters, providing i) how the water-soluble FNs can self-assembled to be the insoluble fibers, ii) How individual fibers can physically recognize neighboring fibers to form a fiber network, and iii) finally, how shapes, and patterned sizes of the charged surface can influence the physical properties of adsorbed FN fibers (size, and direction of fiber formation). We believe that negatively charged surface promotes the adhesion and extension of FN on surface. Charge density and type, types of patterned surfaces, different polymers, PH, Temperature and concentration are of effective parameters.

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