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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Polymorphisms of SUMO4 Gene in Behcet's Patients by Denaturing High-Performance Liquid Chromatography (DHPLC)

등록일
2011년 8월 1일 16시 59분 35초
접수번호
1376
발표코드
Ⅰ-BIO.P-224 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
김경하
단국대학교 화학과, Korea
Small ubiquitin-related modifier 4 (SUMO4) is a post-transcriptional modifier, involved in autoimmune and inflammatory responses through regulaton of NF-κB transcriptional activity. It has been reported that polymorphisms of SUMO4 gene are associated with several autotmmune diseases, such as Behcet's disease (BD), Diabetes, and Vogt-Koyanagi-Harada (VKH) syndrome etc. In this study, we investigated association of genotypes in the SUMO4 gene with BD. Genotyping for SUMO4 polymorphisms at A+163G and C+438T loci was performed on 100 BD patients and 100 controls using denaturing high-performance liquid chromatography (DHPLC). As results, polymorphisms of SUMO4 gene by DHPLC of highly sensitive, specific and rapid technique was able to quickly detected.

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