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초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Inhibition of LPS-induced Nitric Oxide Production in RAW cells by the Leaf Extracts of Tamarindus indica[Ⅲ-미발표]

등록일
2011년 8월 1일 17시 30분 58초
접수번호
1386
발표코드
Ⅲ-MEDI.P-329 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
임순성
한림대학교 식품영양학과, Korea
In this Study, we investigated whether Tamarindus indica leaves extract inhibits lipopolysaccharide (LPS)-induced inflammatory responses in Raw264.7 macrophages. The cells were treated with various concentrations of 85% ethanol extract from T. indica leaves in RAW264.7 cells. LPS-induced nitric oxide (NO) production was inhibited up to 51.2% at 50 μg/mL without any reduction of viable cell numbers. The crude extract of T. indica leaves was further fractionated with hexane, methylene chloride (MC), ethyl acetate (EtOAc), n-butanol, and water. Among the resulting five fractions, MC significantly inhibited LPS-induced NO production (inhibition rate was 43.7% at 5 μg/mL) without significant cytotoxicity in Raw264.7 cells. And also, The main compound was isolated and elucidated the structure from the MC fraction of the leaves of T. indica. As above results, T. indica leaves extract exhibits powerful effects of anti-inflammation and can be used as a cosmetic ingredient.

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