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제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Influence of divalent metal ions on E2-induced ER pathway in goldfish (Carassius auratus) hepatocytes

등록일
2011년 8월 4일 17시 17분 10초
접수번호
1480
발표코드
Ⅰ-BIO.P-226 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
CHANG ZIWEI, LU MING, 박현경1, 박장수1
부산대학교 화학과, China
1부산대학교 화학과, Korea
Metal ions existed in environment could influence the estrogen pathway in aquatic animal, but the detailed mechanism is still delusive. We here showed that in male Carassius auratus hepatocytes, copper (Cu) or cadmium (Cd), did not directly induce vitellogenin (VTG) expression. Interestingly, co-exposure with Cd2+ (or Cu2+) and 17-β-estradiol (E2) greatly increased the VTG level, comparing with single treatment of E2. Meanwhile, Cd2+ or Cu2+ (but not E2) triggers HSP70 expression. But, mixture of Cd2+ or Cu2+ with E2 did not obviously raise HSP70 level. E2 also had no obvious effect on reactive oxygen species. Co-treatment of Cd2+ and E2 showed no obviously increase compared to single treatment with Cd2+. We further assume that Cd2+-involved oxidative stress generates misfolded proteins, resulting in the competition of HSP70 proteins from a heterocomplex (with estrogen receptor). Thus, dissociation of the heterocomplex actives the receptor-ligand binding activity and promotes the E2-induced VTG expression.

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