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제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The oxidative inhibitory effect of eugenol with antioxidant activity on MMP-2 and MMP-9 related to metastasis

2011년 8월 4일 21시 07분 27초
Ⅰ-BIO.P-229 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 <발표Ⅰ>
저자 및
남향, 김문무1
동의대학교 화학과, Korea
1동의대학교 자연대학/화학과, Korea
The oxidative damage of lipid, protein and DNA is known to be involved in chronic inflammation such as arthritis, hepatitis, nephritis, gastritis, colitis and periodontitis. It has been highlighted for searching natural compounds without toxicity which prevent development of these diseases. Thus, we studied whether eugenol(4-allyl-2-methoxy-phenol) can inhibit MMP expression and activity as well as antioxidant effect. Eugenol was contained as a major ingredient of herbs such as clove and Magnoliae Flos. The direct scavenging effects of eugenol on DPPH radical, hydrogen peroxide, reducing power, lipid peroxidation and genomic DNA damage related to oxidative stress were evaluated in cell free system. It was observed that eugenol exhibited higher inhibitory effect on hydrogen peroxide than other reactive oxygen species, and also blocked DNA oxidation and lipid peroxidation induced by hydroxyl radical. In addition, its inhibitory effects on the activity and expression of MMP-9 activity related to metastasis were determined using gelatin zymography and western-blot. The data showed that it inhibited MMP-9 activities in PMA-stimulated HT1080 cells. Furthermore, It was found that eugenol exerts inhibitory effects on MMP-9 via inhibition of p-JNK and p-ERK. Therefore, these results suggest that eugenol could be available as an excellent agent for prevention of metasasis related to oxidative stress.