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학술발표회초록보기

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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Inhibitory Effect of Saponin on Oxidative Stress and Matrix metalloproteinase in Human Dermal Fibroblasts

등록일
2011년 8월 4일 23시 16분 03초
접수번호
1500
발표코드
Ⅰ-BIO.P-230 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
박혜정, 김문무1
동의대학교 화학과, Korea
1동의대학교 자연대학/화학과, Korea
Saponin is a main component of ginseng widely known as a oriental traditional medicinal stuff. A variety of biological efficacy of saponin has been reported but its action related to skin regeneration has remained unclear so far. In this study, the effect of saponin on matrix metalloproteinase as well as antioxidant effect in cell free system was examined in human dermal fibroblasts. First of all, as a result of investigating the effect of saponin on cell viability using MTT assay, it increases cell viability below 10 μg/mL but showed cytotoxicity above 25 μg/mL. The antioxidant effect of saponin was exerted by inhibition on H2O2 in addition to reducing power above 1 μg/mL. In particular, saponin showed a protective effect on DNA oxidation. Furthermore, it was observed that saponin activates MMP-2 and increases MMP-1 activity in gelatin and casein zymography analyses, respectively, indicating that saponin could have a potential possibility as a therapeutic agent for anti-aging and skin regeneration.

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