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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Catechol-functionalized Chitosan/Pluronic Hydrogels for Tissue Adhesives and Hemostatic Materials

등록일
2011년 8월 5일 14시 43분 18초
접수번호
1540
발표코드
Ⅳ-POLY.P-80 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
고분자화학
저자 및
공동저자
유지현, 이해신1
KAIST 나노과학기술대학원, Korea
1KAIST 화학과, Korea

Bio-inspired from adhesion behaviors of mussels, injectable and thermo-sensitive chitosan/Pluronic composite hydrogels were synthesized for tissue adhesives and hemostatic materials. Chitosan conjugated with multiple catechol groups in the backbone was cross-linked with terminally thiolated Pluronic F-127 tri-block copolymer to produce temperature-sensitive and adhesive sol-gel transition hydrogels. A blend mixture of the catechol conjugated chitosan and the thiolated Pluronic F-127 was a viscous solution state at room temperature, but became a cross-linked gel state with instantaneous solidification at the body temperature and physiological pH. The adhesive chitosan/Pluronic injectable hydrogels with remnant catechol groups showed strong adhesiveness to soft tissues and mucous layers, and also demonstrated superior hemostatic properties. These chitosan/Pluronic hydrogels are expected to be usefully exploited for injectable drug delivery depots, tissue engineering hydrogels, tissue adhesives, and anti-bleeding materials.


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