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학술발표회초록보기

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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and evaluation of analogues of KRN7000 containing aromatic ceramide skeleton

등록일
2011년 8월 5일 14시 44분 48초
접수번호
1541
발표코드
ORGN.O-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 40분
발표형식
구두발표
발표분야
유기화학 - Oral Presentation for Young Organic Chemists
저자 및
공동저자
김용주
서울대학교 화학부, Korea
Natural killer T (NKT) cells are a subset of T cells and play a central role in regulating immune responses. The potent immunostimulatory lipid antigens such as KRN7000 have led to activation of NKT cell when presented by CD1d proteins expressed on antigen-presenting cells. In vitro and in vivo studies with NKT cells indicate that the stimulation of NKT cells initiates a cascade of events leading to the release of different Th1- or Th2-type cytokines including proinflammatory (e.g., INF-gamma, TNF-alpha) or immuno-modulatory response (e.g., IL-4, IL-10), respectively. Disruption of the balance betweenTh1 and Th2 cytokines is involved in a broad range of diseases such as infections, cancer, multiple sclerosis, lupus, rheumatoid arthritis and type-1 diabetes. Although several studies of KRN7000 and its derivatives have been reported to confirm structure-activity relationship, almost studies use the similar sphingoid backbone of KRN7000 containing just changes in sphingoid base lengths and in acyl chain. Here, we desrcribe synthesis of a new alpha-galactosylcereamides containing new ceramide skeleton as KRN7000 analogues.

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