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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Metabolomics: challenge in discovery of biomarker and drug target

등록일
2011년 8월 5일 15시 32분 53초
접수번호
1564
발표코드
MEDI-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 15시 : 50분
발표형식
심포지엄
발표분야
의약화학 - New Technology in Drug Discovery
저자 및
공동저자
정봉철
한국과학기술연구원/미래융합기술연구본부, Korea
Metabolomics can provide important information about tumorigenesis, evaluate drug efficacy and identify disease biomarkers in personalized medicine. In this presentation, mass spectrometry (MS) based metabolite profiling combined with multivariate data analysis (MDA) is therefore in-troduced to quantify metabolic changes in various biological samples. The MS based targeted and non-targeted metabolite profiling techniques were validated and applied into the drug efficacy of male-pattern baldness and mining biomarkers of diseases including cervical dysplasia and prostate diseases. For metabolomic pattern analysis, MS data normalized was subjected to the partial-least squares discriminate analysis (PLS-DA). After obtaining the MS data for each metabolite in both targeted and non-targeted metabolite profiling, data were z-score transformed for visualization in the heat-map generated by hierarchical-clustering analysis to allow metabolite signatures. The present study demonstrates that the described GC-MS and LC-MS approaches are potentially useful diagnostic tools and provide an effective means of evaluating the drug efficacy and mining biomarkers in clinical applications.

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