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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Light-Induced Nitric Oxide Releasing from a Ruthenium Nitrosyl Complex : Spectroscopic Properties and Solvent Effects

2012년 2월 14일 16시 26분 48초
INOR.P-149 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 25일 (수요일) 18:00~21:00
저자 및
조장훈, 이홍인
경북대학교 화학과, Korea
Since the discovery of Nitric Oxide (NO) as one of the major signal-transduction molecules in cells, there have been many attempts to devise acute NO-delivering systems for the purpose of developing disease therapies as well as studying cell functions. Metal-nitrosyl complexes are often releasing NO by light activation. This ability can be adapted to killing cancer cells with high specificity because high concentration of NO in cells induces apoptosis. Ru-NO complexes have been studied for the usages of these photodynamic therapy (PDT) agents for a time. In this research, we have developed a new Ru-nitrosyl bis-pyridyl/biscarboxamide compound, [Ru(ebpp)(Cl)(NO)], where H2ebpp = N,N’-(ethylene di-p-phenylene)bis(pyridine-2-carboxamide) to be tested as a model NO-releasing agent.The crystallographic analysis of the complex revealed that the ebpp ligand is tetradentately bound to Ru and the remaining two cis sites of the octahedral geometry are occupied by NO and Cl-. Electronic absorption spectrum of the complex showed two absorption bands are 280 nm and 380 nm. Under the normal room light, 560 nm bands were growing. Simultaneous EPR (electron paramagnetic resonance) experiments at 110 K found that diamagnetic properties of the complex solution changed to a paramagnetic (S =1/2) species. These UV-VIS and EPR data can be interpreted as that the diamagnetic [Ru-NO]6 (Enemark-Feltham notation) electronic state of the complex becomes low-spin Ru(III) (d5, S=1/2) state upon losing NO by photoactivation. We present here other evidences of photoactivated NO-releasing and other properties monitored by UV-VIS, EPR, ESI-MS, X-ray crystallography, and Cyclic Voltammetry (CV) at various conditions.