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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Langmuir Monolayer Study of Mitochondrial Inner Membrane Lipids

2012년 2월 16일 15시 40분 55초
BIO.P-684 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 25일 (수요일) 18:00~21:00
저자 및
Phan Dinh Minh, 신관우1
서강대학교 화학과, Korea
1서강대학교 화학과 및 바이오융합과정, Korea
Mitochondrion is known as a power-house of mammalian cells, where ATP generation is carried out. The three major components composing of the mitochondrial inner membrane are phosphatidylcholine (PC, 40% in weight), phosphatidylethanolamine (PE, 40%) and cardiolipin (CL, 20%). The cardiolipin (CL) is a complex phospholipid only found in the energy-transducing membranes of bacteria and mitochondria. It is known as an essential component in maintaining structure and biological functionality of mitochondrial inner membrane. For better understanding, the mixing properties of CL and other abundant phospholipids in inner membrane of mitochondria, PC, have been investigated. In this work, we have studied ?-A isotherm to understand the compression diagram, and lead to knowledge of thermodynamic and mechanical properties of mixing monolayer as a function of CL content. And we find that at certain amount of cardiolipin, 20% molar fracture, the whole physical properties of mixing monolayer will be ruled as the same of cardiolipin. The fluorescent microscopy, then, is used to visualize the model of CL effects upon mixing monolayer’s properties, as well as prove the role of CL in inducing the 3D folding structure on monolayer system, which is relevant to the interestingly folding structure of cristae in real organelle. Finally, the detail structures of monolayer, in term of electron density profiles, thickness and roughness, at gas phase as reference, pressure of 30mN/m as relevance to lipid packing in real cell, and collapsed phase are characterized at atomic scale by X-ray reflectivity.