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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of capillary electrophoresis inductively coupled plasma mass spectrometry for quantitative analysis of phosphate

등록일
2012년 2월 16일 16시 46분 57초
접수번호
1236
발표코드
ANAL.P-614 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
방수경, 이경석1, 임용현1, 김태규2
한국표준과학연구원 분석화학표준센터, 부산대학교 화학과, Korea
1한국표준과학연구원 분석화학표준센터, Korea
2부산대학교 화학과, Korea
Adenosine phosphates are energy carriers of cell and participate in a metabolic phosphorylation as essential ingredients. Besides, it is possible to get information about specific metabolic pathways through ATP/ADP ratios. For this reasons, their quantitative analysis is very important in biochemical field. Here, we report the development of inductively coupled plasma mass spectrometry (ICP/MS) hyphenated to the capillary electrophoresis (CE) for quantitative analysis of adenosine phosphates. The CE has been applied to separate adenosine tri-phosphate (ATP) and adenosine di-phosphate (ADP). Then, their accurate concentrations were determined through phosphorus measurement by ICP/MS. In addition, metrological traceability to SI has been introduced in the fields of measurement for biomolecules. The limit of detection and dynamic range of phosphorus measurements in these adenosine phosphates by the developed CE-ICP/MS method have been also studied. It is considered as a promising technique in analysing biomolecules owing to its excellent detection limits and selectivity with providing traceability to SI.

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