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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of Catalytic Drug Candidates against Amyloid Diseases

등록일
2012년 2월 16일 16시 50분 49초
접수번호
1242
발표코드
ORGN.O-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 48분
발표형식
구두발표
발표분야
유기화학 - Oral Presentation for Young Organic Chemists
저자 및
공동저자
정근홍
육군사관학교 화학과, Korea
The association of β-sheets, amyloidoses, has been implicated in the formation of protein aggregates and fibrils observed in many human diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), type 2 diabetes (T2DM), spongiform encephalopathies, Huntington’s disease, and familial British dementia (FBD). Drug candidates for amyloidogenic peptides such as β-amyloid 42-mer, α-synuclein, and human islet amyloid polypeptide (h-IAPP) have been recently reported as new therapeutic option by Suh group. Subsequently, we have synthesized more drug candidates on h-IAPP and performed cell tests on INS-1. Recently, those compounds showed cleavage activity against ABri 34-mer which is the major component of the insoluble amyloid deposits that are likely to be involved in familial British dementia. Accordingly, on this research topic, we will continue to synthesize other catalytic drug candidates against amyloid diseases.

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