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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Real-time monitoring nitric oxide and oxygen levels in myocardial ischemia and reperfusion injury in rat heart

등록일
2012년 2월 16일 16시 59분 28초
접수번호
1250
발표코드
ELEC.P-1290 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
전기화학
저자 및
공동저자
김승기, 서보찬, 이기자1, 박헌국1, 신재호
광운대학교 화학과, Korea
1경희대학교 의공학교실, Korea
In recent years, endogenously produced nitric oxide (NO) has been studied broadly because of its role in numerous physiological processes including vasodilator, angiogenesis, neurotransmission, and phagocytosis. Nitric oxide is produced from L-arginine and oxygen (O2) by nitric oxide synthases (NOSs) in vivo. Since endogenously generated NO has been implicated in the control of O2 consumption, it may be essential to monitor O2 levels during NO measurement in physiological milieu. Nitric oxide and oxygen gas sensors based on the electrochemical techniques possess several advantages, including easy miniaturization, high sensitivity, and simple microfabrication for in vivo measurement. These characteristics are suitable for measurement in biological systems. However, the electrooxidation of NO requires a relatively high working potential (+0.8 V vs. Ag/AgCl); thus, other readily oxidizable biological species interfere selective detection of NO. Biofouling (initiated by protein adsorption) at the sensor’s interface is another problem associated with biological measurement of in NO and O2. The electrode surface is then modified with a xerogel membrane to improve the selectivity and prevent protein adsorption. It is well-known that amorphous and hydrophobic perfluoropolymers are highly permeable to various gaseous species including NO and O2. Applying a perfluorinated xerogel-derived gas permeable membrane is allowed to develop an amperometric NO sensor with dramatically improved selectivity, while maintaining high NO permeability. Herein, we demonstrate the utility of the perfluorinated xerogel-modified microsensor to monitor NO and O2 levels in myocardial ischemia and reperfusion injury in vivo. The measurement reflects co-dynamic relationships between NO and O2 contents in rat heart.

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