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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Biomarker Discovery and Diagnostics for Human Health

2012년 2월 16일 17시 44분 53초
ANAL2-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 20분
분석화학 - Recent Advances in Analytical Chemistry II
저자 및
원광대학교 생명나노화학부, Korea
Targeted Glycoproteomics using affinity chromatography (AC) was used for identifying and quantifying cancer-related glycoproteins through cancer and normal plasma on breast cancer. AC has been used to isolate and identify potential cancer biomarker glycoproteins by targeting disease-associated glycans. Glycoproteins were selected from plasma of disease-free and breast cancer patients with narrow selectivity lectin AC column, an anti-Lewis x (Lex) AC column, and an anti-sialyl Lewis x (sLex) AC column. The captured protein fractions were identified and quantified through proteomics procedures. Some proteins were found to be potential breast cancer marker candidates based on their elevation in breast cancer patients. The potential of these candidates as cancer biomarkers remains to be validated in much larger, more diverse populations of breast cancer patients. Our ultimate goal is to develop simple and cheap diagnostics kits by discovering and quantifying disease-related glycoproteins through plasma samples. For this purpose/goal, the first step was to develop protein chips to select and compare proteins among disease samples and individual control ones using antibodies. The disease diagnostic kits have several antibodies which should be immobilized on the inorganic surfaces with their native structures for their activities. Biocompatible polymer coatings were used to build up nanostructures on these chips and then applied to commercialized BioCD products.