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학술발표회초록보기

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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Cytocompatible Encapsulation of Living Chlorella Cells within SiO2-TiO2 Nanocomposite Shells

등록일
2012년 2월 19일 01시 55분 18초
접수번호
1291
발표코드
INOR.P-245 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
무기화학
저자 및
공동저자
고은혜, 최인성
KAIST 화학과, Korea
The artificial shells of hard inorganic nanocomposites on individual living cells would protect the cells against thermal stress, and control cell division. These emerging properties could be combined with cell-surface functionalizations for applications to cell-based biosensors and assays as well as for fundamental studies on single-cell based biology. In this work, individual Chlorella cells were encapsulated within silica/titania nanocomposite shells in a biocompatible method that utilized a designed peptide. The cell viability was maintained, and the division of the encapsulated Chlorella cells was controlled. The cell viability was enhanced compared with the previous work, TiO2-only shell formation. Furthermore, SiO2-TiO2 in our system effectively dissipated heat energy and maintained the cell viability about 7-fold better than the unencapsulated one. For the cell manipulation, magnetic nanoparticles were successfully embedded in the shell. In addition, the incorporation of TiO2 to the shell made it possible to anchor the ligands of interest to the shell via catechol chemistry. All in all, the combination of biological SiO2 and abiolgical TiO2 for the shell formation gave more tunability of the artificial shells compared with the SiO2 or TiO2 shells only.

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