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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Acceleration of Neuritogenesis on Nanostructured Substrates; A Comparative Study on Various Nanotopographies

등록일
2012년 2월 20일 20시 11분 01초
접수번호
1299
발표코드
BIO.P-697 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
강경태
KAIST 화학과, Korea
Nervous system is composed of microstructured scaffolds, which have three-dimensionally designed textures and give biophysical cues to overlying cells in many ways. Since little is known about how nanotopography manipulates neuronal development in vivo, it would provide us a new insight into the developmental processes of brain to elucidate unexplored topographical effects on neurite development. To this end, we introduced 3 types of nanostructures as model surfaces for a comparative study; anodized aluminum oxide (AAO), packed glass beads surfaces (GBeads), and vertically grown silicon nanowires (SiNWs). Various GBeads composed of 100 nm to 660 nm-glass beads, and AAO substrates were used to generate precisely tuned nanotopographies, and we have observed that the acceleration of neurite development occurred on the substrates only with bigger than 200 nm-pitched nanostructures, whose size was comparable with the thickness of filopodia at the tip of the growth cones. For the investigation on biological mechanism of the acceleration, we used SiNWs as an extreme of nanotopography at the effective size range. On SiNWs, we found inhibited formation of F-actin structures (filopodia and lamellipodia). This inhibition would be the major factor to accelerate neurite development, because it might break the F-actin/microtubule balance, causing abnormal proceed of the microtubules.

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