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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Study of myoglobin diversity between horse and sperm whale using TR-WAXS

등록일
2012년 2월 21일 15시 14분 56초
접수번호
1308
발표코드
PHYS.P-493 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
물리화학
저자 및
공동저자
김영민, 김종구, 김태우, 이효철
KAIST 화학과, Korea
Structural dynamics of sperm whale and horse Myoglobin coupled to ligand dissociation by laser irradiation were investigated with Time-Resolved wide angle X-ray solution scattering (TR-WAXS). We have identified the horse myoglobin (eMb) transient movements that happen at 840ps, 34ns, 540ns and 230Mm-1S-1, and sperm whale myoglobin (swMb) transient movements that happen at 460ps, 3.5ns, 92ns and 260Mm-1s-1. Comparing both myoglobin kinetics indicate that sperm whale myoglobin have more fast transient movements, but their recovery times are similar. Also the study shows that horse myoglobin does not have geminate recombination, while sperm whale myoglobin has ~13% germinate recombination. In order to find the reason for the difference between transient movements of eMb and swMb we studied the dynamics of swMb R45K-T68V double mutant that has same amino acid as eMb near heme and the swMb R45K-T68V-I28V triple mutant, that has same amino acid residues as eMb near heme and Xenon site. The results show that the property of amino acids is important factor in the myoglobin kinetics and additionally confirms evolution process between swMb and eMb.

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